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Publications
Identifying PTPRJ As a Novel Mediator of CEBPA-Mutated AML
Alexandra Lubin, Catherine Hockings, Yvette Hoade, Lucy Copper, Phoebe Dace, Catherine Zhu, Helen Brown, Ellen Nuttall Musson, Katie-Jo Miller, Elspeth Payne
Blood. 2023 Nov 28; 142 (Supplement 1): 2755. DOI: https://doi.org/10.1182/blood-2023-177577
Monitoring clone dynamics and reversibility in clonal haematopoiesis and myelodysplastic neoplasm associated with PARP inhibitor therapy—a role for early monitoring and intervention
Ellen Nuttall Musson, Rowan E Miller, Mark R. Mansour, Michelle Lockley, Jonathan Lederman, Elspeth M. Payne
Leukemia. 2023 Nov 17; 38: 215–218. DOI: https://doi.org/10.1038/s41375-023-02040-6
Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis
M. Ferrada, S. Savic, D. Ospina Cardona, J. Collins, H. Alessi, F. Gutierrez-Rodrigues, D. Uthaya Kuma, L. Wilson, W. Goodspeed, J. Topilow, J. Paik, J. Poulter, T. Kermani, M. Koster, K. Warrington, C. Cargo, R. Tattersall, C. Duncan, A. Cantor, P. Hoffmann, E. Payne, H. Bonnekoh, K. Krause, E. Cowen, K. Calvo, B. Patel, A. Ombrello, D. Kastner, N. Young, A. Werner, P. Grayson, D. Beck
Blood. 2022 Sep 29; 140(13):1496-1506. DOI: https://doi.org/10.1182/blood.2022016985
Antibody responses to SARS-CoV-2 vaccination in patients with acute myeloid leukaemia and high risk MDS on active anti-cancer therapies
Wei Yee Chan, Catherine Zhu, Emilie Sanchez, Rajeev Gupta, Adele K. Fielding, Asim Khwaja, Elspeth M. Payne, Jenny O'Nions
Br J Haematol. 2022 May 10; 198(3): 478-481. DOI:https://doi.org/10.1111/bjh.18248
Technologies bringing young Zebrafish from a niche field to the limelight
Jason J. Otterstrom, Alexandra Lubin, Elspeth M. Payne, Yael Paran
SLAS Technol. 2022 Jan 02; 27(2):109-120. DOI: 10.1016/j.slast.2021.12.005
SARS-CoV-2 infection in aplastic anaemia
Daniele Avenoso, Judith C.W. Marsh, Victoria Potter, Antonio Pagliuca, Simon Slade, Fiona Dignan, Eleni Tholouli, Sajjan Mittal, Bernard Davis, Sudhir Tauro, Rachel Kesse-Adu, Morag Griffin, Elspeth M. Payne, Shreyans Gandhi, Austin G. Kulasekararaj
Haematologica. 2022 Feb 01; 107(2):541–543. DOI: https://doi.org/10.3324/haematol.2021.279928
TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation
Oscar A Peña, Alexandra Lubin, Jasmine Rowell, Catherine Hockings, Youngrock Jung, Yvette Hoade, Phoebe Dace, Leonardo E Valdivia, Karin Tuschl, Charlotta Boiers, Maria C Virgilio, Simon Richardson, Elspeth M. Payne
Blood Adv. 2021 Oct 26; 5(20): 4112–4124. DOI: https://doi.org/10.1182/bloodadvances.2020003055
A versatile, automated and high-throughput drug screening platform for zebrafish embryos
Alexandra Lubin , Jason Otterstrom, Yvette Hoade, Ivana Bjedov , Eleanor Stead, Matthew Whelan , Gaia Gestri, Yael Paran, Elspeth M. Payne
Biol Open. 2021 Sep 02;10(9). DOI: https://doi.org/10.1242/bio.058513.
Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish
Oscar A. Peña, Alexandra Lubin, Jasmine Rowell, Yvette Hoade, Noreen Khokhar, Hanna Lemmik, Christopher Mahony, Phoebe Dace, Chianna Umamahesan, Elspeth M. Payne
Front. Cell Dev. Biol. 2021 Sep 13; 9. DOI: https://doi.org/10.3389/fcell.2021.708113
Guidelines for the Management Adult Myelodysplastic Syndromes
Sally B. Killick, Wendy Ingram, Dominic Culligan, Helen Enright, Jonathan Kell, Elspeth M. Payne, Pramila Krishnamurthy, Austin Kulasekararaj, Manoj Raghavan, Simon J. Stanworth, Simone Green, Ghulam Mufti, Lynn Quek, Catherine Cargo, Gail L. Jones, Juliet Mills, Alex Sternberg, Daniel H. Wiseman, David Bowen
Br J Haematol. 2021 Jun 27;194(2):267-81 DOI: https://doi.org/10.1111/bjh.17612
Guidelines for the diagnosis and evaluation of prognosis of adult myelodysplastic syndromes
Sally B. Killick, Daniel H. Wiseman, Lynn Quek, Catherine Cargo, Dominic Culligan, Helen Enright, Simone Green, Wendy Ingram, Gail L. Jones, Jonathan Kell, Pramila Krishnamurthy, Austin Kulasekararaj, Juliet Mills, Ghulam Mufti, Elspeth M. Payne, Manoj Raghavan, Simon J. Stanworth, Alex Sternberg, David Bowen, British Society for Haematology
Br J Haematol. 2021 Jun 16; 194(2):282-93. DOI: https://doi.org/10.1111/bjh.17621
Successful use of allogeneic bone marrow transplantation in a patient with myelodysplastic syndrome presenting with autoimmune manifestations.
Giulia Simini, Strachan Mackenzie, Satyen Gohil, Xenofon Papanikolaou, Jessica Manson, Elspeth M. Payne
Br. J. Haematol. 2021 Apr 11; 193: 1275-1277. DOI: https://doi.org/10.1111/bjh.17437
Successful remission induction therapy with gilteritinib in a patient with de novo FLT3-mutated acute myeloid leukaemia and severe COVID-19
Andrew J. Wilson, Ethan Troy-Barnes, Maryam Subhan, Fiona Clark, Rajeev Gupta, Adele K. Fielding, Panagiotis Kottaridis, Marc R. Mansour, Jenny O'Nions, Elspeth M. Payne, Naina Chavda, Robert Baker, Kirsty Thomson, Asim Khwaja
Br J Haematol. 2020 Jun 25; 190: e189-e191. DOI: https://doi.org/10.1111/bjh.16962
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
A. Rio-Machin, To. Vulliamy, N. Hug, A. Walne, K. Tawana, S. Cardoso, A. Ellison, N. Pontikos, J. Wang, H. Tummala, A. Fahad H. A. Seraihi, J. Alnajar, F. Bewicke-Copley, H. Armes, M. Barnett, A. Bloor, C. Bödör, D. Bowen, P. Fenaux, A. Green, A. Hallahan, H. Hjorth-Hansen, U. Hossain, S. Killick, S. Lawson, M. Layton, A. Male, J. Marsh, P. Mehta, R. Mous, J. Nomdedéu, C. Owen, J. Pavlu, E. Payne, R. Protheroe, C. Preudhomme, N. Pujol-Moix, A. Renneville, N. Russell, A. Saggar, G. Sciuccati, D. Taussig, C. Toze, A. Uyttebroeck, P. Vandenberghe, B. Schlegelberger, T. Ripperger, D. Steinemann, J. Wu, J. Mason, P. Page, S. Akiki, K. Reay, J. Cavenagh, V. Plagnol, J. Caceres, J. Fitzgibbon, I. Dokal
Nat Commun. 2020 Feb 25; 11: 1044. DOI: https://doi.org/10.1038/s41467-020-14829-5
In Trans Early Mosaic Mutational Escape and Novel Phenotypic Features of Germline SAMD9 Mutation
Catherine Hockings, Satyen Gohil, Robin Dowse, Yvette Hoade, Marc R. Mansour, Rosemary E. Gale, David C. Linch, Anupama Rao, Elspeth M. Payne
Br J Haematol. 2020 Jan 03;188(4):e53–e57. DOI: https://doi.org/10.1111/bjh.16322
Clinical outcomes and survival of patients with myeloma and lymphoma enrolled into phase I clinical trials
Dima El-Sharkawi, Chin-Hin Ng, Elspeth M. Payne, Kwee L. Yong, Kirit M. Ardeshna, Asim Khwaja, William Townsend, Rakesh Popat
Br J Haematol, 2019 Apr 1; 185: 344-347. DOI: https://doi.org/10.1111/bjh.15457
Intensive Chemotherapy Is Associated With Poor Overall Survival in Autoimmune Disease-associated Myeloid Malignancies
Simon E. Richardson, Duncan Brian, Victoria Grandage, Rachael Hough, Panagiotis Kottaridis, Marc R. Mansour, Elspeth M. Payne, Asim Khwaja
HemaSphere, 2019 Feb 01; 3(1). DOI: http://doi.org/10.1097/HS9.0000000000000164.
DNAJC21 mutations link a cancer prone bone marrow failure syndrome to corruption in 60S ribosome subunit maturation
Hemanth Tummala, Amanda J Walne, Mike Williams, Nicholas Bockett, Laura Collopy, Shirleny Cardoso, Alicia Ellison, Rob Wynn, Thierry Leblanc, Jude Fitzgibbon, David P Kelsell, David A van Heel, Elspeth M. Payne, Vincent Plagnol, Inderjeet Dokal, Tom Vulliamy
Am J Hum Genet. 2016 Jul 7;99(1):115-24. DOI: http://doi.org/10.1016/j.ajhg.2016.05.002
Ribosomal Proteins Rps19 and Rps14 Cooperate As Tumor Suppressor Genes with p53
Maria Virgilio, Grzegorz Pietka, Elspeth M. Payne
Blood. 2014 Dec 06; 124 (21): 2943. DOI: https://doi.org/10.1182/blood.V124.21.2943.2943
L-leucine improves the anemia in models of Diamond-Blackfan anemia and the 5q- syndrome in a p53-independent way
Anupama Narla, Elspeth M. Payne, Nirmalee Abayasekara, Slater Hurst, David Raiser, A. Thomas Look, Nancy Berliner, Benjamin Ebert, Arati Khanna-Gupta
Br J Haematol. 2014 Nov;167(4):524-528. DOI: https://doi.org/10.1111/bjh.13069
Molecular Basis of Cancer. Chapter 8: Animal Models: Flies, Fish, and Yeast
Elspeth M. Payne and A. Thomas Look
Mendelsohn et al, 2014 Feb 19, 4th ed. Thompson Elsevier Health Sciences
The zebrafish as a tool to study hematopoiesis, human blood diseases, and immune function
Jason Berman, Elspeth M. Payne, Christopher Hall
Adv Hematol. Special Issue. 2012 Oct 03; Article ID 425345. DOI:https://doi.org/10.1155/2012/425345
L-Leucine Improves the Anemia and Developmental Defects Associated With Diamond-Blackfan Anemia and del(5q) MDS by Activating the mTOR Pathway
Elspeth M. Payne, Maria Virgilio, Anupama Narla, Hong Sun, Michelle Levine, Barry H Paw, Nancy Berliner, A Thomas Look, Benjamin Ebert, Arati Khanna-Gupta
Blood. 2012 Sep 13;120(11):2214-24. DOI:https://doi.org/10.1182/blood-2011-10-382986
Myelopoiesis and myeloid leukaemogenesis in the zebrafish
A. Michael Forrester, Jason N. Berman, Elspeth M. Payne
Adv Hematol. 2012 Jul 19; 120(11):2214-2224. DOI:https://doi.org/10.1155/2012/358518
NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis
A. Michael Forrester, Clemens Grabher, Eileen R McBride, Ellen R Boyd, Märta H Vigerstad, Alexander Edgar, Fui-Boon Kai, Sahar I Da'as, Elspeth M. Payne, A. Thomas Look, Jason N Berman
Br J Haematol. 2011 Oct; 155(2):167-81. DOI: https://doi.org/10.1111/j.1365-2141.2011.08810.x
Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia
Alejandro Gutierrez, Ruta Grebliunaite, Hui Feng, Elena Kozakewich, Shizhen Zhu, Feng Guo, Elspeth M. Payne, Marc Mansour, Suzanne Dahlberg, Donna Neuberg, Jeroen den Hertog, Edward Prochownik, Joseph Testa, Marian Harris, John Kanki, A. Thomas Look
J Exp Med. 2011 Aug 1;208(8):1595-603. DOI: https://doi.org/10.1084/jem.20101691.
Ddx18 is essential for cell cycle progression in zebrafish hematopoietic cells and is mutated in human acute myeloid leukemia
Elspeth M. Payne, Niccolò Bolli, Jennifer Rhodes, Omar I. Abdel-Wahab, Ross Levine, Cyrus V. Hedvat, Richard Stone, Arati Khanna-Gupta, Hong Sun, John P. Kanki, Hanna T. Gazda, Alan H. Beggs, Finbarr E. Cotter, A. Thomas Look
Blood. 2011 Jul 28; 118(4):903-15. DOI: https://doi.org/10.1182/blood-2010-11-318022
Cpsf1 is required for definitive hematopoietic stem cell survival in zebrafish
Niccolò Bolli, Elspeth M. Payne, Jennifer Rhodes, Evisa Gjini, Adam B Johnston, Feng Guo, Jeong-Soo Lee, Rodney A Stewart, John P Kanki, Aye T Chen, Yi Zhou, Leonard I Zon, A. Thomas Look
Blood. 2011 Apr 14;117(15):3996-4007. DOI: https://doi.org/10.1182/blood-2010-08-304030
Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb
Clemens Grabher, Elspeth M. Payne, Adam B. Johnston, Niccolo Bolli, Eric Lechman, John E. Dick, John P. Kanki, A. Thomas Look
Leukemia. 2011 Mar; 25(3):506-14. DOI: https://doi.org/10.1038/leu.2010.280
Endothelial Von Willebrand Factor Regulates Angiogenesis
Richard D. Starke, Francesco Ferraro, Koralia Paschalaki, Nicola Dryden, Thomas McKinnon, Rachel Sutton, Elspeth M. Payne, Dorian Haskard, Alun Hughes, Daniel Cutler, Mike Laffan, Anna Randi
Blood. 2011 Jan 20; 117(3):1071-80. DOI: 10.1182/blood-2010-01-264507
Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of primitive myeloid cells and definitive hematopoietic stem cells in zebrafish
Niccolò Bolli, Elspeth M. Payne, Clemens Grabher, Jeong-Soo Lee, Adam B. Johnston, Brunangelo Falini, John P. Kanki, A. Thomas Look
Blood. 2010 Apr 22;115(16):3329-40. DOI:https://doi.org/10.1182/blood-2009-02-207225
Zebrafish Modeling of Leukaemias
Elspeth M. Payne and A Thomas Look
Br J Haematol. 2009 Aug; 146(3):247-5609. DOI: https://doi.org/10.1111/j.1365-2141.2009.07705.x
Efficacy of recombinant activated factor VII in unselected patients with uncontrolled haemorrhage: a single centre experience
Elspeth M. Payne, Stephen J Brett, Michael A Laffan
Blood Coag Fib. 2006 Jul; 17(5):397-402. DOI: https://doi.org/10.1097/01.mbc.0000233370.49099.c0
ABO incompatibility due to immunoglobulin G anti‐B antibodies presenting with severe fetal anaemia
Jenny H. Ziprin, Elspeth M. Payne, L. Hamidi, I. Roberts, F. Regan
Transfus Med. 2005 Feb; 15(1):57-60. DOI: https://doi.org/10.1111/j.1365-3148.2005.00549.x.
Clinical Effects and P-glycoprotein Inhibition in Patients With Acute Myeloid Leukemia Treated With Zosuquidar Trihydrochloride, Daunorubicin and Cytarabine
Gareth Gerrard, Elspeth M. Payne, Robert Baker, Dylan Jones, Michael Potter, H. Grant Prentice, Mark Ethell, Heather McCullough, Michael Burgess, Atul Mehta, Kanagasabai Ganeshaguru
Hematologica 2004 July; 89(7): 782-90.
Effect of anti-CD20 (Rituximab) on resistant thrombocytopenia in Autoimmune Lymphoproliferative Syndrome
Bridget T Heelan, Vincent Tormey, Peter Amlot, Elspeth M. Payne, Atul Mehta, A David B Webster
BrJ Haematol. 2002 Sep; 118(4): 1078-81. DOI: 10.1046/j.1365-2141.2002.03753.x
Electrical cardioversion for atrial fibrillation: outcomes in ‘real-life’ clinical practice
Colin Berry, Simon Stewart, Elspeth M. Payne, John D McArthur, John J.V McMurray
In J Cardiol. 2001 Nov; 81(1):29-35. DOI:https://doi.org/10.1016/S0167-5273(01)00522-8
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