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Publications

Identifying PTPRJ As a Novel Mediator of CEBPA-Mutated AML

Alexandra Lubin, Catherine Hockings, Yvette Hoade, Lucy Copper, Phoebe Dace, Catherine Zhu, Helen Brown, Ellen Nuttall Musson, Katie-Jo Miller, Elspeth Payne
Blood. 2023 Nov 28; 142 (Supplement 1): 2755. DOI: https://doi.org/10.1182/blood-2023-177577

 

Monitoring clone dynamics and reversibility in clonal haematopoiesis and myelodysplastic neoplasm associated with PARP inhibitor therapy—a role for early monitoring and intervention

Ellen Nuttall Musson, Rowan E Miller, Mark R. Mansour, Michelle Lockley, Jonathan Lederman, Elspeth M. Payne
Leukemia. 2023 Nov 17; 38: 215–218. DOI: https://doi.org/10.1038/s41375-023-02040-6
 

Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis

M. FerradaS. SavicD. Ospina CardonaJ. CollinsH. AlessiF. Gutierrez-RodriguesD. Uthaya KumaL. WilsonW. GoodspeedJ. TopilowJ. PaikJ. PoulterT. KermaniM. KosterK. WarringtonC. CargoR. TattersallC. DuncanA.  CantorP. HoffmannE. PayneH. BonnekohK. KrauseE. CowenK. CalvoB. PatelA. OmbrelloD. KastnerN. Young, A. WernerP. GraysonD. Beck
Blood. 2022 Sep 29; 140(13):1496-1506. DOI: https://doi.org/10.1182/blood.2022016985

Antibody responses to SARS-CoV-2 vaccination in patients with acute myeloid leukaemia and high risk MDS on active anti-cancer therapies

Wei Yee Chan, Catherine Zhu, Emilie Sanchez, Rajeev Gupta, Adele K. Fielding, Asim Khwaja, Elspeth M. Payne, Jenny O'Nions
Br J Haematol. 2022 May 10; 198(3): 478-481. DOI:https://doi.org/10.1111/bjh.18248

Technologies bringing young Zebrafish from a niche field to the limelight

Jason J. OtterstromAlexandra LubinElspeth M. Payne, Yael Paran 
SLAS Technol. 2022 Jan 02; 27(2):109-120. DOI: 10.1016/j.slast.2021.12.005

SARS-CoV-2 infection in aplastic anaemia

Daniele Avenoso, Judith C.W. Marsh, Victoria Potter, Antonio Pagliuca, Simon Slade, Fiona Dignan, Eleni Tholouli, Sajjan Mittal, Bernard Davis, Sudhir Tauro, Rachel Kesse-Adu, Morag Griffin, Elspeth M. PayneShreyans Gandhi, Austin G. Kulasekararaj
Haematologica. 2022 Feb 01; 107(2):541–543. DOI: https://doi.org/10.3324/haematol.2021.279928

TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation

Oscar A Peña, Alexandra Lubin, Jasmine Rowell, Catherine Hockings, Youngrock Jung, Yvette Hoade, Phoebe Dace, Leonardo E Valdivia, Karin Tuschl, Charlotta Boiers, Maria C Virgilio, Simon Richardson, Elspeth M. Payne
Blood Adv. 2021 Oct 26; 5(20): 4112–4124. DOI: https://doi.org/10.1182/bloodadvances.2020003055

A versatile, automated and high-throughput drug screening platform for zebrafish embryos

Alexandra Lubin , Jason Otterstrom, Yvette Hoade, Ivana Bjedov , Eleanor Stead, Matthew Whelan , Gaia Gestri, Yael Paran, Elspeth M. Payne
Biol Open.​ 2021 Sep 02;10(9). DOI: https://doi.org/10.1242/bio.058513.

Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish

Oscar A. Peña, Alexandra Lubin, Jasmine Rowell, Yvette Hoade, Noreen Khokhar, Hanna Lemmik, Christopher Mahony, Phoebe Dace, Chianna Umamahesan, Elspeth M. Payne
Front. Cell Dev. Biol. 2021 Sep 13; 9. DOI: https://doi.org/10.3389/fcell.2021.708113

Guidelines for the Management  Adult Myelodysplastic Syndromes

Sally B. KillickWendy IngramDominic CulliganHelen EnrightJonathan KellElspeth M. PaynePramila KrishnamurthyAustin KulasekararajManoj RaghavanSimon J. StanworthSimone GreenGhulam MuftiLynn QuekCatherine CargoGail L. JonesJuliet MillsAlex SternbergDaniel H. WisemanDavid Bowen
Br J Haematol. 2021 Jun 27;194(2):267-81 DOI: https://doi.org/10.1111/bjh.17612

Guidelines for the diagnosis and evaluation of prognosis of adult myelodysplastic syndromes

Sally B. Killick, Daniel H. Wiseman, Lynn Quek, Catherine Cargo, Dominic Culligan, Helen Enright, Simone Green, Wendy Ingram, Gail L. Jones, Jonathan Kell, Pramila Krishnamurthy, Austin Kulasekararaj, Juliet Mills, Ghulam Mufti, Elspeth M. Payne, Manoj Raghavan, Simon J. Stanworth, Alex Sternberg, David Bowen, British Society for Haematology
Br J Haematol. 2021 Jun 16; 194(2):282-93. DOI: https://doi.org/10.1111/bjh.17621

Successful use of allogeneic bone marrow transplantation in a patient with myelodysplastic syndrome presenting with autoimmune manifestations.

Giulia Simini,  Strachan Mackenzie,  Satyen Gohil,  Xenofon Papanikolaou,  Jessica Manson,  Elspeth M. Payne
Br. J. Haematol. 2021 Apr 11; 193: 1275-1277. DOI: https://doi.org/10.1111/bjh.17437

Successful remission induction therapy with gilteritinib in a patient with de novo FLT3-mutated acute myeloid leukaemia and severe COVID-19

Andrew J. Wilson,  Ethan Troy-Barnes,  Maryam Subhan,  Fiona Clark,  Rajeev Gupta,  Adele K. Fielding,  Panagiotis Kottaridis,  Marc R. Mansour,  Jenny O'Nions,  Elspeth M. Payne,  Naina Chavda,  Robert Baker,  Kirsty Thomson,  Asim Khwaja
Br J Haematol. 2020 Jun 25; 190: e189-e191. DOI: https://doi.org/10.1111/bjh.16962

 

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

A. Rio-MachinTo. VulliamyN. HugA. WalneK. TawanaS. CardosoA. EllisonN. PontikosJ. WangH. TummalaA. Fahad H. A. SeraihiJ. AlnajarF. Bewicke-CopleyH. ArmesM. BarnettA. BloorC.  BödörD. BowenP. FenauxA. Green, A. HallahanH. Hjorth-HansenU. HossainS. KillickS. LawsonM.  LaytonA. MaleJ. MarshP. MehtaR. Mous, J. NomdedéuC. OwenJ. PavluE. PayneR. ProtheroeC. PreudhommeN. Pujol-MoixA. RennevilleN.  RussellA. SaggarG. SciuccatiD.  TaussigC. TozeA. UyttebroeckP. VandenbergheB. SchlegelbergerT. RippergerD. SteinemannJ. WuJ. MasonP. PageS. AkikiK. ReayJ. CavenaghV. PlagnolJ. CaceresJ. Fitzgibbon, I. Dokal
Nat Commun. 2020 Feb 25; 11: 1044. DOI: https://doi.org/10.1038/s41467-020-14829-5

In Trans Early Mosaic Mutational Escape and Novel Phenotypic Features of Germline SAMD9 Mutation

Catherine Hockings, Satyen Gohil, Robin Dowse, Yvette Hoade, Marc R. Mansour, Rosemary E. Gale, David C. Linch, Anupama Rao, Elspeth M. Payne
Br J Haematol. 2020 Jan 03;188(4):e53–e57. DOI: https://doi.org/10.1111/bjh.16322

Clinical outcomes and survival of patients with myeloma and lymphoma enrolled into phase I clinical trials

Dima El-Sharkawi,  Chin-Hin Ng,  Elspeth M. Payne,  Kwee L. Yong,  Kirit M. Ardeshna,  Asim Khwaja,  William Townsend, Rakesh Popat
Br J Haematol, 2019 Apr 1; 185: 344-347. DOI: https://doi.org/10.1111/bjh.15457

Intensive Chemotherapy Is Associated With Poor Overall Survival in Autoimmune Disease-associated Myeloid Malignancies

Simon E. RichardsonDuncan BrianVictoria GrandageRachael HoughPanagiotis KottaridisMarc R. MansourElspeth M. PayneAsim Khwaja
HemaSphere, 2019 Feb 01; 3(1). DOI: http://doi.org/10.1097/HS9.0000000000000164.

DNAJC21 mutations link a cancer prone bone marrow failure syndrome to corruption in 60S ribosome subunit maturation

Hemanth Tummala, Amanda J Walne, Mike Williams, Nicholas Bockett, Laura Collopy, Shirleny Cardoso, Alicia Ellison, Rob Wynn,  Thierry Leblanc, Jude Fitzgibbon,  David P Kelsell, David A van Heel, Elspeth M. Payne, Vincent Plagnol, Inderjeet Dokal, Tom Vulliamy
Am J Hum Genet. 2016 Jul 7;99(1):115-24. DOI: http://doi.org/10.1016/j.ajhg.2016.05.002

Ribosomal Proteins Rps19 and Rps14 Cooperate As Tumor Suppressor Genes with p53

Maria Virgilio, Grzegorz Pietka, Elspeth M. Payne
Blood. 2014 Dec 06; 124 (21): 2943. DOI: https://doi.org/10.1182/blood.V124.21.2943.2943

 

L-leucine improves the anemia in models of Diamond-Blackfan anemia and the 5q- syndrome in a p53-independent way

Anupama Narla, Elspeth M. Payne, Nirmalee Abayasekara, Slater Hurst, David Raiser, A. Thomas Look, Nancy Berliner, Benjamin Ebert, Arati Khanna-Gupta
Br J Haematol. 2014 Nov;167(4):524-528. DOI: https://doi.org/10.1111/bjh.13069

Molecular Basis of Cancer. Chapter 8: Animal Models: Flies, Fish, and Yeast

Elspeth M. Payne and A. Thomas Look
Mendelsohn et al, 2014 Feb 19, 4th ed. Thompson Elsevier Health Sciences

The zebrafish as a tool to study hematopoiesis, human blood diseases, and immune function

Jason Berman, Elspeth M. Payne, Christopher Hall
Adv Hematol. Special Issue. 2012 Oct 03; Article ID 425345. DOI:https://doi.org/10.1155/2012/425345

L-Leucine Improves the Anemia and Developmental Defects Associated With Diamond-Blackfan Anemia and del(5q) MDS by Activating the mTOR Pathway

Elspeth M. PayneMaria VirgilioAnupama NarlaHong SunMichelle LevineBarry H PawNancy BerlinerA Thomas LookBenjamin EbertArati Khanna-Gupta
Blood. 2012 Sep 13;120(11):2214-24. DOI:https://doi.org/10.1182/blood-2011-10-382986

Myelopoiesis and myeloid leukaemogenesis in the zebrafish

A. Michael Forrester, Jason N. Berman, Elspeth M. Payne
Adv Hematol. 2012 Jul 19; 120(11):2214-2224. DOI:https://doi.org/10.1155/2012/358518

NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis

A. Michael Forrester, Clemens Grabher, Eileen R McBride, Ellen R Boyd, Märta H Vigerstad, Alexander Edgar, Fui-Boon Kai, Sahar I Da'as, Elspeth M. Payne, A. Thomas Look, Jason N Berman
Br J Haematol. 2011 Oct; 155(2):167-81. DOI: https://doi.org/10.1111/j.1365-2141.2011.08810.x

 

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

Alejandro GutierrezRuta GrebliunaiteHui FengElena KozakewichShizhen ZhuFeng GuoElspeth M. PayneMarc MansourSuzanne DahlbergDonna NeubergJeroen den HertogEdward ProchownikJoseph TestaMarian HarrisJohn KankiA. Thomas Look
J Exp Med. 2011 Aug 1;208(8):1595-603. DOI: https://doi.org/10.1084/jem.20101691.

 

Ddx18 is essential for cell cycle progression in zebrafish hematopoietic cells and is mutated in human acute myeloid leukemia

Elspeth M. PayneNiccolò BolliJennifer RhodesOmar I. Abdel-WahabRoss LevineCyrus V. HedvatRichard StoneArati Khanna-GuptaHong SunJohn P. KankiHanna T. GazdaAlan H. BeggsFinbarr E. Cotter,  A. Thomas Look
Blood. 2011 Jul 28; 118(4):903-15. DOI: https://doi.org/10.1182/blood-2010-11-318022

 

Cpsf1 is required for definitive hematopoietic stem cell survival in zebrafish

Niccolò BolliElspeth M. PayneJennifer RhodesEvisa GjiniAdam B JohnstonFeng GuoJeong-Soo LeeRodney A StewartJohn P KankiAye T ChenYi ZhouLeonard I ZonA. Thomas Look
Blood. 2011 Apr 14;117(15):3996-4007. DOI: https://doi.org/10.1182/blood-2010-08-304030

 

Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb

Clemens Grabher, Elspeth M. Payne,  Adam B. Johnston, Niccolo Bolli,  Eric Lechman, John E. Dick, John P. Kanki, A. Thomas Look
Leukemia. 2011 Mar; 25(3):506-14. DOI: https://doi.org/10.1038/leu.2010.280

 

Endothelial Von Willebrand Factor Regulates Angiogenesis

Richard D. Starke, Francesco Ferraro, Koralia Paschalaki, Nicola Dryden, Thomas McKinnon, Rachel Sutton, Elspeth M. Payne, Dorian Haskard, Alun Hughes, Daniel Cutler, Mike  Laffan, Anna Randi
Blood. 2011 Jan 20; 117(3):1071-80. DOI: 10.1182/blood-2010-01-264507

 

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of primitive myeloid cells and definitive hematopoietic stem cells in zebrafish

Niccolò Bolli, Elspeth M. Payne, Clemens Grabher, Jeong-Soo Lee, Adam B. Johnston, Brunangelo Falini, John P. Kanki, A. Thomas Look
Blood. 2010 Apr 22;115(16):3329-40. DOI:https://doi.org/10.1182/blood-2009-02-207225

 

Zebrafish Modeling of Leukaemias

Elspeth M. Payne and A Thomas Look
Br J Haematol. 2009 Aug; 146(3):247-5609. DOI: https://doi.org/10.1111/j.1365-2141.2009.07705.x

 

Efficacy of recombinant activated factor VII in unselected patients with uncontrolled haemorrhage: a single centre experience

Elspeth M. Payne, Stephen J Brett, Michael A Laffan
Blood Coag Fib. 2006 Jul; 17(5):397-402. DOI: https://doi.org/10.1097/01.mbc.0000233370.49099.c0

ABO incompatibility due to immunoglobulin G anti‐B antibodies presenting with severe fetal anaemia

Jenny H. Ziprin, Elspeth M. Payne, L. Hamidi, I. Roberts, F. Regan
Transfus Med. 2005 Feb; 15(1):57-60. DOI: https://doi.org/10.1111/j.1365-3148.2005.00549.x.

 

Clinical Effects and P-glycoprotein Inhibition in Patients With Acute Myeloid Leukemia Treated With Zosuquidar Trihydrochloride, Daunorubicin and Cytarabine

Gareth GerrardElspeth M. PayneRobert BakerDylan JonesMichael PotterH. Grant PrenticeMark EthellHeather McCulloughMichael BurgessAtul MehtaKanagasabai Ganeshaguru
Hematologica 2004 July; 89(7): 782-90.

Effect of anti-CD20 (Rituximab) on resistant thrombocytopenia in Autoimmune Lymphoproliferative Syndrome

Bridget T HeelanVincent TormeyPeter AmlotElspeth M. PayneAtul MehtaA David B Webster
BrJ Haematol. 2002 Sep; 118(4): 1078-81. DOI: 10.1046/j.1365-2141.2002.03753.x

Electrical cardioversion for atrial fibrillation: outcomes in ‘real-life’ clinical practice

Colin Berry, Simon Stewart, Elspeth M. Payne, John D McArthur, John J.V McMurray
In J Cardiol. 2001 Nov; 81(1):29-35. DOI:https://doi.org/10.1016/S0167-5273(01)00522-8
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