Dr Elspeth (Beth) Payne MBChB PhD
I studied medicine at the University of Glasgow, intercalating at University College London in Psychology. I went on to complete my clinical post-graduate training in internal medicine in Oxford and Glasgow, followed by Specialist Haematology Training in London. I undertook my PhD at the Dana-Farber Cancer Institute in Boston with Professor Tom Look on a T32 training fellowship from Harvard School of Public Health and the Greg Harper Clinical Research Training Fellowship from the LLR-UK (now Bloodwise), studying ribosomal protein mediated disorders using zebrafish. I returned to UCL with a Wellcome Trust Intermediate Clinical Fellowship and Beit-Prize to continue some of this work and currently hold a CRUK Advanced Clinician Scientist Fellowship. I remain clinically active and am clinical lead at University College London Hospital for patients with Bone Marrow Failure and MDS.
Outside of the lab I love to spend time doing power yoga and relaxing with my two young children.
Dr Alexandra Lubin PhD
I studied Natural Sciences at Jesus College at the University of Cambridge, specialising in Chemistry and graduating with my masters in 2014. From there I moved to Imperial College London where I completed my PhD in Chemical Biology ‘Epigenetic therapeutics in malaria – a chemical biological approach towards the validation of histone lysine methyltransferase inhibition in P. falciparum.’
I joined the Payne Lab as a post-doc in 2018. My main project involves developing a high-throughput automated drug screen in live zebrafish embryos, to screen for novel compounds that are synthetic lethal to stem cells that carry mutations that are common in MDS and AML, in particular Dnmt3a.
Outside the lab I enjoy cooking, wine tasting and going on holiday!
I graduated from the University of Bristol in 2017 with a degree in Cellular and Molecular Medicine. During this time, I also completed a year in industry at GSK, in which I tested novel drugs, known as PROTACs, which target specific intracellular proteins for proteasomal degradation.
I joined the Payne Lab in 2018. My main project involves creating a transgenic zebrafish to model clonal heterogeneity and evolution of MDS.
Outside the lab, I enjoy playing tag rugby and netball, cycling, skiing, growing plants and playing the piano.
Whilst studying Biochemistry at the University of Bath, I took a placement year at the University of Oxford, where I used cell lines to research drug repurposing and combination therapies for cancer. After graduating in 2015, I started work as a technician in the Cross Lab (University of Southampton), based at the Wessex Regional Genetics Laboratory in Salisbury. I developed assays and screened samples from patients with unexplained hypereosinophilia for genetic mutations.
I moved to the Payne Lab in 2018, where I have enjoyed learning about zebrafish and take an active role in lab management and running the Haematology Biobank. As part of my main project I have optimised a semi-automated DNA extraction method and am extracting DNA from thousands of patient samples. This DNA will be sequenced for mutations that occur naturally as part of the ageing process but can predispose patients to ageing related diseases, including leukaemia and cardiovascular disease.
In my spare time, I enjoy baking cakes and playing board games and I am in the process of learning how to sew.
I am a molecular biologist with a BSc (IND) Biological Sciences degree from the University of Leeds (Graduated 2019). My year in industry was with the GE Healthcare viral vector team in Stevenage. As part of the viral vector team I was working towards the aim of increasing the speed and efficiency of AAV purification.
I joined the Payne Lab in September 2019. My project is entitled cancer and ageing: studying leukaemia & blood stem cell exhaustion in short-lived African killifish. Developing a novel model organism for blood cancer research is an exciting challenge that I hope to make significant progress in.
Outside of the lab I enjoy board games, video games, skiing, and play a lot of netball.
Funded by CRUK.
Past lab members
Dr Catherine Hockings
MRC Clinical Research Fellow
Thesis title: Secondary driver mutations in CEBPA-mutated acute myeloid leukaemia.
PhD viva in February 2020.
Dr Oscar Peña
Thesis title: Modelling haematopoietic malignancies using zebrafish.
Oscar received his PhD in February 2019.
MSc Students and Destinations
MSc Cancer (UCL): Harsha Bhatnagar - Distinction (PhD student, University of Zurich)
MSc Human Genetics (Imperial): Nour Halibi - Merit
MSc Human Genetics (Imperial): Christos Nicolau
MSc Human Genetics (Imperial): Noreen Khokhar - Distinction (BBSRC LIDO PhD Student, London )
MSc Genetics of Human Disease (UCL): Victoria Deaner - Distinction
MSc Human Genetics (Imperial): Hanna Lemmik - Distinction (Wellcome Trust PhD Student, London)
MSc Human Genetics (Imperial): Laura J Bruce - Distinction (Masters in Public Health and Epidemiology, Rutgers, New York)
MSc Human Genetics (Imperial): Katrina Stone - Distinction (Clinical Academic, UCL)
MSc Pharmacogenetics and Stratified Medicine (UCL): Sarah Hoang – Distinction
MSc Cancer (UCL): Chianna Umamahesan (PhD - Kings College London)
MSc Cancer (UCL): Andrea Michael - Merit (PhD - KIT, Germany )
MSc Drug Development (UCL): Youngrock Jung - Distinction (PhD - Imperial, London)
MSc Human Genetics (Imperial): Ioannis Moustakas - Merit (Medical School, Athens)
Tiffany Soon – BSc Biological Sciences 2:1
Ann-Marie Tong – BSc Biochemistry - 1st class (Medical School-Hong Kong)
Jasmine Rowell – Research Technician (BBSRC LIDO PhD Student, London)
Greg Contento – Research Technician (MRC PhD Student, UCL)
Greg Pietka – Post-Doc (Research Scientist, Royal Marsden Hospital)
Maria Virgilio – Research Technician (PhD Student)