In the Payne Lab at the UCL Cancer Institute, we study bone marrow failure and myelodysplastic syndromes (MDS). We use a combination of approaches to study these disorders, modelling them using zebrafish and using samples from patients to validate our findings.
Our research focuses on specific mutations that can cause predisposition to MDS. This can be as a result of genetic conditions, such as the ribosomopathies Diamond-Blackfan anaemia and 5q- syndrome, or due to normal age-related clonal haematopoiesis known as CHIP. Ageing and CHIP are at the core of our current research projects, as we investigate the mutations and risk factors that can predispose the ageing population to MDS and acute myeloid leukaemia (AML).
The goal of our research is to understand the molecular mechanisms of the diseases we study and to screen for novel therapeutics.