In the Payne Lab at UCL Cancer Institute we study bone marrow failure and myelodysplastic syndromes (MDS). These conditions can be challenging to study because patient cells are difficult to grow outside the body. Therefore we use a combination of approaches, modeling the diseases we study in the zebrafish and using samples from patients to validate our findings. We are particularly interested in the ribosomopathies Diamond -Blackfan Anaemia and MDS5q, as well as conditions with a genetic predisposition to MDS . Pre-disposition to MDS may occur due to germ line mutations but also due to normal age-related clonal haematopoiesis.
The overarching goal of our research is to understand the molecular mechanisms of the diseases we study and to screen for novel therapeutics.